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IRS recruitment activates phosphoinositide 3-kinase (PI3K), which phosphorylates PIP2 to PIP3, recruiting Akt/PKB to the membrane for activation by PDK1 this PI3K/Akt arm drives protein synthesis via mTORC1, glucose uptake via GLUT4 translocation, and cell survival via BAD phosphorylation
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Declining glutathione is linked with fatigue, dull skin, and faster visible aging [14]
Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB
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